The deglycosylated form of 1E12 inhibits platelet activation and prothrombotic effects induced by VITT antibodiesArticle Published on 2022-10-012022-11-15 Journal: Haematologica [Category] 진단, [키워드] activate Activation addition adenoviral vector vaccine antibodies antibody Autoimmune bind chimeric COVID-19 COVID-19 vaccines demonstrated Effect epitope Fc fragment granulocyte help IgG antibodies immune IMPROVE induce inhibit interact Mouse models NETosis neutralize Neutrophils overlapping Pathogenesis pathogenic pathophysiology PF4 Platelet platelet activation Prevent prothrombotic receptors recognize Support thrombosis thrombotic Trigger Whole blood [DOI] 10.3324/haematol.2021.280251 PMC 바로가기
The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variantsArticle Published on 2022-09-072022-10-06 Journal: Science Translational Medicine [Category] SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome Administered Anti-SARS-CoV-2 Activity antiviral drug antiviral efficacy antiviral potency coronavirus coronavirus disease COVID-19 delta variant demonstrated driving Efficacy exhibited GS-441524 in vitro K18-hACE2 mice lung damage Mouse models oral administration oral bioavailability pandemic parent nucleoside parental prophylactically reduced viral load Remdesivir SARS-CoV-2 SARS-CoV-2 transmission vaccination variant variants of concern virus VoC VOCs [DOI] 10.1126/scitranslmed.abm7621 PMC 바로가기 [Article Type] Article
A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 InfectionSARS-CoV-2 감염에 대한 항바이러스제의 효능을 평가하기 위한 SCID 마우스 모델Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 치료제, [키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral drug antiviral drugs antiviral efficacy antivirals B.1.351 B.1.351 variant BALB/c Beta Beta variant binding C57BL/6 CAGE coronavirus Culture drug hamsters Infection infectious virus titer infectious virus titers Infective dose inhibitors intrinsic lack log lung Lung pathology Lungs male mice Model moderate molnupiravir mouse mouse model Mouse models Nirmatrelvir nirmatrelvir. offer Postinfection reagent receptor reduced replicate Replication reported SARS-CoV-2 SARS-CoV-2 mouse model SARS-CoV-2 strain SARS-CoV2 SCID significantly TCID These data tissue tissue culture twice a day Validity variant variants variants of concern Viral load virus virus strain wild-type [DOI] 10.1128/jvi.00758-22 PMC 바로가기 [Article Type] Article
Comparison of model-specific histopathology in mouse models of COVID-19Article Published on 2022-08-012023-07-08 Journal: Journal of medical virology [Category] COVID19(2023년), [키워드] ACE2 Histopathology Mouse models pneumonia. SARS-CoV-2 [DOI] 10.1002/jmv.27747 PMC 바로가기
A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions액세서리 단백질이 결실된 생약독화 SARS-CoV-2 백신 후보Article Published on 2022-07-272022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] Antiviral approved biosafety cultures deleted Deletion hamster hamsters immunization interferon interferon signaling K18-hACE2 live-attenuated vaccine mNeonGreen Mouse models neutralization ORF ORF3a ORFs Phosphorylation primary human airway PROTECT Protein replicate Replication reporter Research SARS-CoV-2 SARS-CoV-2 vaccine sequence Stat1 Transmission vaccine production Vero-E6 cell Viral viral transcription virus wild-type SARS-CoV-2 wild-type virus [DOI] 10.1038/s41467-022-31930-z PMC 바로가기 [Article Type] Article
Cancer vaccines: Building a bridge over troubled watersReview article Published on 2022-07-132022-10-05 Journal: Cell [Category] 비임상, [키워드] Antigen approaches building Cancer Cancer cells help highlight immune system Mouse models natural immunity post-vaccination responses recent single-cell unique Vaccine [DOI] 10.1016/j.cell.2022.06.035 [Article Type] Review article
Molnupiravir inhibits SARS-CoV-2 variants including Omicron in the hamster modelMolnupiravir는 햄스터 모델에서 Omicron을 포함한 SARS-CoV-2 변이체를 억제합니다Article Published on 2022-07-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 변종, [키워드] Administered Adults Alpha Analysis Antiviral approved Beta caused COVID-19 Delta VOC delta VoCs demonstrated drug drug therapy effective Efficacy examined hamster hamsters Histopathologic analysis identify infectious titer infectious titers inhibit inhibited inhibitory effect Lower respiratory tract lung Lung disease Lungs Measures mechanism molnupiravir mouse Mouse models mutagenic mutated nucleoside omicron Preexisting immunity reduction in Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 lineage SARS-CoV-2 variant SARS-CoV-2 variants Spike protein the SARS-CoV-2 Treatment upper and lower respiratory tract variant Viral antigen viral RNA genome Virology Virology. virus replication VoC VOCs was reduced [DOI] 10.1172/jci.insight.160108 PMC 바로가기 [Article Type] Article
Animal models for COVID-19: advances, gaps and perspectivesCOVID-19에 대한 동물 모델: 발전, 격차 및 전망Review Published on 2022-07-072022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 바이오마커, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] ADE animal animal model animal models Antibody-dependent enhancement caused cells Characteristics clinical feature Clinical features combinations Comorbidity COVID-19 evaluate ferret host receptor Host receptors hosts human tissue human tissues immune response immune responses Infection livestock mice mouse model Mouse models mouse-adapted strain non-human primates outbreak pandemic Pathogenesis pathogenesis of SARS-CoV-2 Perspective populations poultry protease Proteases receptor receptors SARS-CoV-2 SARS-COV-2 infection strain susceptible therapy transduced transgenic variants variants of concern virulence VoC [DOI] 10.1038/s41392-022-01087-8 PMC 바로가기 [Article Type] Review
K18- and CAG-hACE2 Transgenic Mouse Models and SARS-CoV-2: Implications for Neurodegeneration ResearchK18- 및 CAG-hACE2 형질전환 마우스 모델 및 SARS-CoV-2: 신경변성 연구에 대한 시사점Review Published on 2022-06-282022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] absence ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral drug Autopsy Brain brain regions brain tissue CAG-hACE2 transgenic mice caused cells Central nervous system Confusion Consequences coronavirus COVID-19 COVID-19 patient COVID-19 patients Cytokines demonstrated develop direct infection disorder disorders dissect Encephalitis entry receptor enzyme evaluate glial cell global pandemic hACE2 helping human Angiotensin-converting enzyme Human brain increase in infected with SARS-CoV-2 Inflammation K18 K18-transgenic mice leukocyte leukocyte infiltration life manifestation mechanism Meningitis Mental Model molecular mouse Mouse models mucosa neuroinvasion. neurological Neurological complication Neurological complications neuronal neurons olfactory Patient periphery pro-inflammatory cytokine pro-inflammatory cytokines provoke Quality of life reported responses robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus suggested survivor therapy transgenic Transgenic mouse Vaccine development [DOI] 10.3390/molecules27134142 PMC 바로가기 [Article Type] Review
Mouse models in COVID-19 research: analyzing the adaptive immune responseReview Published on 2022-06-042023-06-16 Journal: Medical Microbiology and Immunology [Category] COVID19(2023년), MERS, SARS, [키워드] COVID-19 Mouse models SARS-CoV-2 specific T cells [DOI] 10.1007/s00430-022-00735-8 PMC 바로가기 [Article Type] Review